| name | category | nominated work | year |
|---|---|---|---|
| American Comedy Award | Cheers | 1991 | |
| Carol Burnett Award | Funniest Male Performer in a Television Series | 2025 | |
| Critics' Choice Award | Best Actor in a Comedy Series | Cheers | 2017 |
| Golden Globe Award | Best Actor – Miniseries or Television Film | Something About Amelia | 1984 |
| Golden Globe Award | Best Actor – Television Series Musical or Comedy | Cheers | 1989 |
| Golden Globe Award | Best Actor – Television Series Musical or Comedy | Cheers | 1990 |
| Primetime Emmy Award | Outstanding Lead Actor in a Comedy Series | Cheers | 1990 |
| Primetime Emmy Award | Outstanding Lead Actor in a Comedy Series | Cheers | 1993 |
| Primetime Emmy Award | Bob Hope Humanitarian Award | 2025 |